IF you want no one to open a drive without your permission.
it is possible in Windows 7 ultimate/premium
To block access to drive go to Computer and right click on the drive and select properties. In the properties window click on ‘Security’ tab. Select the user account you want to restrict and click on edit.
Change the permissions according to your need for user groups or a particular user and click Apply and then OK. It will not work for users with admin account as even they have the same rights as you so they can revert all permissions. You will need an admin account to perform this task.
NOTE:This trick is for Windows 7 ultimate and premium edition users only